Prime Minister David Cameron and President Barack Obama have said they are both "gravely concerned" over "increasing signs" that an alleged chemical weapons attack took place in Syria.
The two leaders spoke with Canada Prime Minister Stephen Harper by telephone last night as calls increase for UN investigators already in the country to be allowed access to the site of the alleged attack.
A Downing Street spokesperson stressed that any significant use of chemical weapons would merit a "serious response".
The spokesperson added: "The fact that President Assad has failed to cooperate with the UN suggests that the regime has something to hide.
Medecins Sans Frontieres has said 355 people died in the attack "They reiterated that significant use of chemical weapons would merit a serious response from the international community and both have tasked officials to examine all the options.
"They agreed that it is vital that the world upholds the prohibition on the use of chemical weapons and deters further outrages."
US Defence Secretary Chuck Hagel said the military is ready to exercise "options" on Syria should force be called for, but he declined to say what that action might be.
The attacks took place in the Damascus suburbs of Zamalka and Ein Tarma He is under mounting pressure to act over the alleged use of chemical weapons, which humanitarian organisation Medecins Sans Frontieres (MSF) said had killed 355 people due to "neurotoxic" symptoms.
The group said victims flooded three Syrian hospitals after a "chemical massacre" on Wednesday.
MSF director of operations Bart Janssens said the reported symptoms "strongly indicate mass exposure to neurotoxic agent".
He said: "Medical staff working in these facilities provided detailed information to MSF doctors regarding large numbers of patients arriving with symptoms including convulsions, excess saliva, pinpoint pupils, blurred vision and respiratory distress.
A boy recovers after the alleged toxic gas attack on Wednesday "The reported symptoms of the patients, in addition to the epidemiological pattern of the events - characterised by the massive influx of patients in a short period of time, the origin of the patients, and the contamination of medical and first aid workers - strongly indicate mass exposure to a neurotoxic agent."
Rebel groups have claimed the attack was carried out by Assad's forces and that more than 1,000 people had died. The Syrian regime has denied the allegations.
On Saturday, Iran warned the West against military intervention in Syria and claimed the alleged gas attack was carried out by rebels.
UN disarmament chief Angela Kane has arrived in the capital to press the Assad regime to allow weapon inspectors to assess whether a chemical attack has taken place.
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